Analysis of a Fractional-Order Mathematical Model of Gonorrhea Transmission with Control Measures
Abstract
Gonorrhea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. It spreads primarily through sexual contact and can affect the genital tract, rectum, and throat. If left untreated, it may lead to serious health complications, including infertility and increased susceptibility to other infections. This study investigated the transmission dynamics of gonorrhea using a fractional-order mathematical model to evaluate the effects of treatment, vaccination, and contact rates on disease spread. The model established the existence and uniqueness of solutions within the fractional-order framework, confirming that it is well-posed. Stability analysis is conducted to better understand disease behavior, including the computation of the basic reproduction number. The results revealed that increasing treatment rates among infected individuals plays a crucial role in reducing the reproduction number below one, which is necessary for disease control. In contrast, higher contact rates contribute to increased transmission and help sustain the presence of the disease within the population. Simulation results further show that transmission-related parameters promote disease spread, while treatment-related parameters reduce infection levels, thereby lowering the overall disease burden. The dynamics of different population compartments under varying treatment and contact rates are examined using the fractional Adams–Bashforth–Moulton numerical scheme. The findings emphasized that effective treatment of infected individuals is essential for reducing the burden of gonorrhea. The study concludes that combining expanded treatment strategies with reduced transmission pathways is vital for controlling and potentially eradicating the disease in the population.
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References
Unemo, M., Seifert, H. S., Hook, E. W., Hawkes, S., Ndowa, F., & Dillon, J.-A. R. (2019). Gonorrhoea. Nature Reviews Disease Primers, 5, 79. https://doi.org/10.1038/s41572-019-0128-6
Kirkcaldy, R. D., Weston, E., Segurado, A. C., & Hughes, G. (2019). Epidemiology of gonorrhea: A global perspective. Sexual Health, 16(5), 401–411. https://doi.org/10.1071/SH19061
Lin, E. Y., Adamson, P. C., & Klausner, J. D. (2021). Epidemiology, treatments, and vaccine development for antimicrobial-resistant Neisseria gonorrhoeae: Current strategies and future directions. Drugs, 81(10), 1153–1169. https://doi.org/10.1007/s40265-021-01530-0
World Health Organization. (2021). Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021. World Health Organization. https://www.who.int/publications/i/item/9789240027077
Rowley, J., Vander Hoorn, S., Korenromp, E., Low, N., Unemo, M., Abu-Raddad, L. J., Chico, R. M., Smolak, A., Newman, L., Gottlieb, S., Thwin, S. S., Broutet, N., & Taylor, M. M. (2019). Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016. Bulletin of the World Health Organization, 97(8), 548–562P. https://doi.org/10.2471/BLT.18.228486
Chidiac, O., AlMukdad, S., Harfouche, M., Harding-Esch, E. M., & Abu-Raddad, L. J. (2024). Epidemiology of gonorrhoea: Systematic review, meta-analyses, and meta-regressions. Eurosurveillance, 29(9), 2300226. https://doi.org/10.2807/1560-7917.ES.2024.29.9.2300226
Quillin, S. J., & Seifert, H. S. (2019). Neisseria gonorrhoeae host adaptation and pathogenesis. Nature Reviews Microbiology, 17(4), 226–240. https://doi.org/10.1038/s41579-019-0170-4
Rice, P. A. (2020). Gonococcal arthritis (disseminated gonococcal infection). Infectious Disease Clinics of North America, 34(2), 355–368. https://doi.org/10.1016/j.idc.2020.02.003
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., Ouellette, M., Outterson, K., Patel, J., Cavaleri, M., Cox, E. M., Houchens, C. R., Grayson, M. L., Hansen, P., Singh, N., Magrini, N. (2019). Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria. The Lancet Infectious Diseases, 19(3), 318–327. https://doi.org/10.1016/S1473-3099(18)30798-4
Colón Pérez, J., Villarino Fernández, R.-A., Domínguez Lago, A., Treviño Castellano, M. M., Pérez del Molino Bernal, M. L., Sánchez Poza, S., & Torres-Sangiao, E. (2024). Addressing sexually transmitted infections caused by Neisseria gonorrhoeae: Current challenges and future perspectives. Microorganisms, 12(5), 884. https://doi.org/10.3390/microorganisms12050884
Adedayo, O. A., Ayobami, S. L., Muhammed, A. S., & Musa, O. I. (2023). Mathematical modeling of gonorrhea treatment dynamics with incorporating control measures. Global Scientific Journal.
Al Basir, F., & Abraha, T. (2023). Mathematical modelling and optimal control of malaria using awareness-based interventions. Mathematics, 11(7), 1687.
https://doi.org/10.3390/math11071687
Ayoub, H. H., Tomy, M., Chemaitelly, H., Omori, R., Buse, K., Low, N., Hawkes, S., & Abu-Raddad, L. J. (2024). Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study. Epidemics, 48, 100785.
https://doi.org/10.1016/j.epidem.2024.100785
Oke, S. I., Ojo, M. M., Adeniyi, M. O., & Matadi, M. B. (2020). Mathematical modeling of malaria disease with control strategy. Communications in Mathematical Biology and Neuroscience, 2020, Article ID 43.
https://doi.org/10.28919/cmbn/4513
Reichert, E., Yaesoubi, R., Rönn, M. M., Gift, T. L., Salomon, J. A., & Grad, Y. H. (2023). Resistance-minimising strategies for introducing a novel antibiotic for gonorrhoea treatment: A mathematical modelling study. The Lancet Microbe, 4(10), e781–e789.
https://doi.org/10.1016/S2666-5247(23)00171-4
Ullah, I., Ahmad, I., Ali, N., Ahmad, H., & Ul Haq, I. (2024). Mathematical modeling and analysis of dynamics of Neisseria gonorrhea disease with self protection, treatment and natural immunity.
https://www.researchgate.net/publication/388194121
Hamenyimana, E. G., Opoku, N. K.-D. O., & Ibrahim, S. (2018). Mathematical modelling of human African trypanosomiasis using control measures. Computational and Mathematical Methods in Medicine, 2018, 5293568. https://doi.org/10.1155/2018/5293568
Fatoba, O. J., Atuji, S. S., Dashe, N. E., Akogwu, B. O., Ukoh, E. E., & Udoh, I. J. (2023).Mathematical modelling and stability analysis of monkey pox transmission dynamics in Nigeria. FUDMA Journal of Sciences, 7(5), 247–257. https://doi.org/10.33003/fjs-2023-0705-2017
Cassidy, R., Singh, N. S., Schiratti, P. R., Semwanga, A., Binyaruka, P., Sachingongu, N., Chama-Chiliba, C. M., Chalabi, Z., Borghi, J., & Blanchet, K. (2019).
Mathematical modelling for health systems research: A systematic review of system dynamics and agent-based models. BMC Health Services Research, 19, 845. https://doi.org/10.1186/s12913-019-46
Wang, X., & Zou, X. (2017). Modeling the fear effect in predator–prey interactions with adaptive avoidance of predators. Bulletin of Mathematical Biology, 79(6), 1325–1359. https://doi.org/10.1007/s11538-017-0287-0
Baskonus, H. M., & Bulut, H. (2015). On the numerical solutions of some fractional ordinary differential equations by fractional Adams–Bashforth–Moulton method. Open Mathematics, 13(1), 547–556. https://doi.org/10.1515/math-2015-0052
Diethelm, K. (1999). Fractional differential equations: Theory and numerical treatment. TU Braunschweig. Diethelm fractional differential equations reference (TU Braunschweig)
Tang, Q., & Ma, Q. (2015). Variational formulation and optimal control of fractional diffusion equations with Caputo derivatives. Advances in Difference Equations, 2015, 283. https://doi.org/10.1186/s13662-015-0593-5
Caputo, M., & Fabrizio, M. (2015). A new definition of fractional derivative without singular kernel. Progress in Fractional Differentiation and Applications, 2, 73–85.
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