Investigating the Prevalence, associated Risk Factors of Community-Acquired Acute Kidney Injury among hospitalized COVID-19 Patients at Almarj Teaching Hospital, Libya
Keywords:
Community-Acquired Acute Kidney Injury, COVID-19, Impact, Prevalence, Risk Factors
Abstract
Abstract: With a variety of consequences resulting from the disease, the COVID-19 pandemic has had a substantial influence on global health. Among these, acute kidney damage (AKI) has become a serious issue, especially for patients who are admitted to hospitals. Acute kidney damage (AKI) affects about 10% of these patients.
Objective: Evaluating the prevalence of CA-AKI and determine risk factors and knowing how this illness affects COVID-19 mortality.
Methods: single-centered retrospective study which was conducted in 2024. It encompassed the medical records of hospitalized patients with severe Covid-19 infection patients who were admitted to isolation department of Elmarj Teaching Hospital in a specific period from August 21, 2020 to December 31 2021.
Results: Community acquired acute kidney injury (CA-AKI) was observed in 55 patients (31.3%).Among non-survivors, 78.2% experiencing AKI. In comparison, among survivors and only 21.8%. Predictors of CA-AKI in COVID-19 patients based on logistic regression. Age, Systolic blood pressure (SBP) and SO2. Conversely, oxygen saturation (SO2) was negatively correlated with AKI.
Conclusion: About one third of COVID-19 patients developed CA-AKI .These patients had higher mortality rate. CA-AKI were associated with aging, comorbidity and clinical aspect of patient. We recommend that healthcare providers closely observe kidney function and implement effective multimodal therapies when managing patients with COVID-19.
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References
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22-Anastasia Shchepalina, , Natalia Chebotareva, Larissa Akulkina , Mikhail Brovko , Viktoria Sholomova , Tatiana Androsova , Yulia Korotchaeva , Diana Kalmykova , Elena Tanaschuk , Marina Taranova , Marina Lebedeva, Vladimir Beketov and Sergey Moiseev. Acute Kidney Injury in Hospitalized Patients with COVID-19: Risk Factors and Serum Biomarkers. Biomedicines 2023, 11, 1246. https://doi.org/10.3390/biomedicines11051246
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24.Filipe Marques , Joana Gameiro , João Oliveira , José Agapito Fonseca , Inês Duarte , João Bernardo, Carolina Branco , Claúdia Costa , Carolina Carreiro, Sandra Braz and José António Lope. Acute Kidney Disease and Mortality in Acute Kidney Injury Patients with COVID-19. J. Clin. Med. 2021, 10, 4599. https://doi.org/10.3390/jcm10194599.
2. Sabaghian, T., Kharazmi, A., Ansari, M., Omidi, F., Kazemi, M., Hajikhani, B., Vaziri-Harami, R., Tajbakhsh, A., Omidi, S., Haddadi, M., Shahidi Bonjar, S., Nasiri, N., &Mirsaeidi, M. (2022). COVID-19 and Acute Kidney Injury: A Systematic Review. Frontiers in Medicine, 9. doi:10.3389/fmed.2022.
3 .Mansour, H.M., & Alshahrani, M.S. (2022). COVID-19-associated AKI. PMC. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC9612421/
4 .Al Otaibi T, Nagib A, Nair P, Halim MA, Khaled M, Hammad MA, Mahmoud TS, Sobhy I, Zakaria Z, Atta A, Deraz A, Mostafa A, Abuelmagd M, Shaker M, Alserwy N, Fyyad Z, Rida S, Aboatya H, Adel M, Balaha M, Atea K, Gheith O. Acute Kidney Injury Among COVID-19-Positive Patients Is Associated With Higher Mortality: A Single-Center Experience. Exp Clin Transplant. 2024 Jan;22(Suppl 1):290-298. doi: 10.6002/ect.MESOT2023.P98. PMID: 38385415.
5 .Chow EJ, Rolfes MA, O’Halloran A, et al. Respiratory and nonrespiratory diagnoses associated with influenza in hospitalized adults. JAMANetw Open. 2020;3(3):e201323. doi:10.1001/jamanetworkopen.2020.1323
6 .Shusterman E, Kliuk Ben-Bassat O, Zahler D, et al. Risk factors, clinical characteristics and prognostic value of acute kidney injury in COVID-19 compared with influenza virus and respiratory syncytial virus. J Nephrol. 2023;36:1-11. doi:10.1007/s40620-023-01591-2
7 .Birkelo BC, Parr SK, Perkins AM, et al. Comparison of COVID-19 versus influenza on the incidence, features, and recovery from acute kidney injury in hospitalized United States veterans. Kidney Int. 2021;100(4):894-905. doi:10.1016/j.kint.2021.05.029
8 .Strohbehn IA, Zhao S, Seethapathy H, et al. Acute kidney injury incidence, recovery, and long-term kidney outcomes among hospitalized patients with COVID-19 and influenza. Kidney Int Rep. 2021;6(10):2565-2574. doi:10.1016/j.ekir.2021.07.008
9 .Aklilu, A.M., Kumar, S., Nugent, J., et al. (2024). COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine, 184(4), 414–423. doi:10.1001/jamainternmed.2023.8225.
10 . Xu, Z., Tang, Y., Huang, Q. et al. Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19. BMC Nephrol 22, 52 (2021). https://doi.org/10.1186/s12882-021-02244-x
11 .Bagshaw S.M., Uchino S., Bellomo R. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol. 2007;2(3):431–439. doi: 10.2215/CJN.03681106.
12 .van den Akker J.P.C., Egal M., Groeneveld A.B.J. Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis. Crit Care (London, England) 2013;17(3):R98. doi: 10.1186/cc12743.
13 .Saito S., Uchino S., Takinami M., Uezono S., Bellomo R. Postoperative blood pressure deficit and acute kidney injury progression in vasopressor-dependent cardiovascular surgery patients. Crit Care. 2016;20(1):74. doi: 10.1186/s13054-016-1253-1.
14. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney inter., Suppl. 2012; 2:1–138.
15. Pickering, John W.; Endre, Zoltán H.. Back-Calculating Baseline Creatinine with MDRD Misclassifies Acute Kidney Injury in the Intensive Care Unit. Clinical Journal of the American Society of Nephrology 5(7):p 1165-1173, July 2010. | DOI: 10.2215/CJN.08531109
16.Schaubroeck, H.; Vandenberghe, W.; Boer, W.; Boonen, E.; Dewulf, B.; Bourgeois, C.; Dubois, J.; Dumoulin, A.; Fivez, T.; Gunst, J.; et al. Acute Kidney Injury in Critical COVID-19: A Multicenter Cohort Analysis in Seven Large Hospitals in Belgium. Crit. Care 2022, 26, 225. [CrossRef]
17.Alice Ruault , Carole Philipponnet , Vincent Sapin , Bertrand Evrard, RadhiaBouzgarrou , Laure Calvet , François Thouy , KévinGrapin , Benjamin Bonnet, Mireille Adda , Bertrand Souweine and Claire Dupuis.Epidemiology and Outcome of Early-Onset Acute Kidney Injury and Recovery in Critically Ill COVID-19 Patients: A Retrospective Analysis.Biomedicines 2023, 11, 1001. https://doi.org/10.3390/biomedicines11041001
18.Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020 May;97(5):829-838. doi: 10.1016/j.kint.2020.03.005. Epub 2020 Mar 20. PMID: 32247631; PMCID: PMC7110296.
19.Fabrizi F, Alfieri CM, Cerutti R, Lunghi G, Messa P. COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis. Pathogens. 2020 Dec 15;9(12):1052. doi: 10.3390/pathogens9121052. PMID: 33334023; PMCID: PMC7765425.
20.Khruleva, Yulia; Mubayazvamba, Tapiwa; Troitskaya, Elena; Efremovtseva, Marina; Kobalava, Zhanna. HYPERTENSION IS A RISK FACTOR FOR ACUTE KIDNEY INJURY AND A PREDICTOR OF MORTALITY IN HOSPITALIZED PATIENTS WITH COVID-19. Journal of Hypertension 39():p e406, April 2021. | DOI: 10.1097/01.hjh.0000749296.26490.d9
21. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11. Erratum in: Lancet. 2020 Mar 28;395(10229):1038. doi: 10.1016/S0140-6736(20)30606-1. Erratum in: Lancet. 2020 Mar 28;395(10229):1038. doi: 10.1016/S0140-6736(20)30638-3. PMID: 32171076; PMCID: PMC7270627.
22-Anastasia Shchepalina, , Natalia Chebotareva, Larissa Akulkina , Mikhail Brovko , Viktoria Sholomova , Tatiana Androsova , Yulia Korotchaeva , Diana Kalmykova , Elena Tanaschuk , Marina Taranova , Marina Lebedeva, Vladimir Beketov and Sergey Moiseev. Acute Kidney Injury in Hospitalized Patients with COVID-19: Risk Factors and Serum Biomarkers. Biomedicines 2023, 11, 1246. https://doi.org/10.3390/biomedicines11051246
23.Muriel Ghosn , Nizar Attallah, Mohamed Badr , Khaled Abdallah , Bruno De Oliveira , Ashraf Nadeem , Yeldho Varghese , Dnyaseshwar Munde , Shameen Salam , Baraa Abduljawad , Khaled Saleh , Hussam Elkambergy , Ali Wahla , Ahmed Taha , Jamil Dibu , Ahmed Bayrlee , Fadi Hamed , Nadeem Rahman and Jihad Mallat . Severe Acute Kidney Injury in Critically Ill Patients with COVID-19 Admitted to ICU: Incidence, Risk Factors, and Outcomes.J. Clin. Med. 2021, 10, 1217. https://doi.org/10.3390/jcm10061217
24.Filipe Marques , Joana Gameiro , João Oliveira , José Agapito Fonseca , Inês Duarte , João Bernardo, Carolina Branco , Claúdia Costa , Carolina Carreiro, Sandra Braz and José António Lope. Acute Kidney Disease and Mortality in Acute Kidney Injury Patients with COVID-19. J. Clin. Med. 2021, 10, 4599. https://doi.org/10.3390/jcm10194599.
Published
2025-02-20
How to Cite
Khalifa, A., ALqathafy, K., & Salah, A. (2025). Investigating the Prevalence, associated Risk Factors of Community-Acquired Acute Kidney Injury among hospitalized COVID-19 Patients at Almarj Teaching Hospital, Libya. GPH-International Journal of Biological & Medicine Science, 8(01), 33-45. https://doi.org/10.5281/zenodo.14899684
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