HEMATOLOGICAL RESTORATION EFFECT OF HUNTERIAL UMBELLATA FRUIT EXTRACT ON PHENYLHYDRAZINE INDUCED ANEMIA IN WISTAR RATS
Abstract
This study investigated the hematological potential abilities of Hunteria Umbellata whole fruit aqueous extract in normal and phenylhydrazine-induced anemia in male Wistar rats. The research animals were divided into four groups of ten per group Anemia was induced in group 3 and group 4 with phenylhydrazine at 0.5ml body weight. Group3 was treated at 500mg/kg body weight orally with the fruit extract daily while group 4 was treated at 250mg/kg daily. Group 2 was treated at 200mg/kg extract daily without induction of anemia with phenylhydrazine to test the proactiveness of the whole fruit extract in the normotensive group. The group1 was administered feeds and water daily ad libitum. The results from the present study shows that the group3 treated at the high dose of 500mg/kg extract daily had the highest full blood counts with regards to hemoglobin concentration, red blood cell, white blood cell, and platelets counts (82.85g/dl), (44.60) x10¹², (101.85)10⁹ and platelets (480)10⁹ respectively at the end of the twenty-eight days of study. The basophil percentage were all 0% in both groups. However, the neutrophil count was elevated in group 2 (27.00%) and group 3 (13.50%) followed by the control (13.00%) group and finally group 4 with (12.50%0 respectively. Furthermore, the percentage of the eosinophils and monocytes was elevated in group 2 above other groups during the course of the study. The correlation of PCV and HB versus other blood parameters all shows a positive correlations and significant p-values among the variables. This study has proved the hematological restorative potentials of Hunteria Umbellata whole fruit extract Physio pharmacological dose effect during anemic conditions back toward normal by stimulating mechanisms that will lead to erythropoiesis, leukocytosis, and thrombocytosis.
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